Background: Studies of the efficacy of vitamin C treatment for fatigue have yielded inconsistent results. One of\r\nthe reasons for this inconsistency could be the difference in delivery routes. Therefore, we planned a clinical trial\r\nwith intravenous vitamin C administration.\r\nMethods: We evaluated the effect of intravenous vitamin C on fatigue in office workers. A group of 141 healthy\r\nvolunteers, aged 20 to 49 years participated in this randomized, double-blind, controlled clinical trial. The trial\r\ngroup received 10 grams of vitamin C with normal saline intravenously, while the placebo group received normal\r\nsaline only. Since vitamin C is a well-known antioxidant, oxidative stress was measured. Fatigue score, oxidative\r\nstress, and plasma vitamin C levels were measured before intervention, and again two hours and one day after\r\nintervention. Adverse events were monitored.\r\nResults: The fatigue scores measured at two hours after intervention and one day after intervention were\r\nsignificantly different between the two groups (p = 0.004); fatigue scores decreased in the vitamin C group after\r\ntwo hours and remained lower for one day. Trial also led to higher plasma vitamin C levels and lower oxidative\r\nstress compared to the placebo group (p < 0.001, p < 0.001, respectively). When data analysis was refined by\r\ndividing each group into high-baseline and low-baseline subgroups, it was observed that fatigue was reduced in\r\nthe lower baseline vitamin C level group after two hours and after one day (p = 0.004). The same did not hold for\r\nthe higher baseline group (p = 0.206).\r\nConclusion: Thus, intravenous vitamin C reduced fatigue at two hours, and the effect persisted for one day. There\r\nwere no significant differences in adverse events between two groups. High dose intravenous vitamin C proved to\r\nbe safe and effective against fatigue in this study.
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